Jos Zegers started his musical career on the oboe at the age of 8. In 2001, alongside his studies in Business Economics at Maastricht University, he began his oboe studies at Conservatorium Maastricht, where he graduated with honors in 2006. In 2011, he once again graduated with honors, this time in conducting, from the Royal Conservatoire The Hague. In 2009, he reached the semi-finals of the international conducting competition at the World Music Contest in Kerkrade, becoming the youngest participant at the time. In 2015, he won the international conducting competition "Con Brio" in Innsbruck, Austria, once again as the youngest participant.
From 2016 to 2022, he served as the chief conductor of the Bundespolizeiorchester München, a 46-member professional orchestra. He also worked as a guest conductor with the Polizeiorchester Bayern and has been leading the Fanfare Eensgezindheid Maasbracht since 2018. In February 2019, he made his debut as a guest conductor with the Munich Symphony Orchestra.
As of October 1, 2022, he has been appointed as the chief conductor of the Fanfare "Bereden Wapens" in Vught. Additionally, as of September 1, 2022, he has been appointed as the main subject teacher for Wind/Brass Band Conducting Conservatorium Maastricht. He is also actively involved as a jury member with the KNMO (Royal Dutch Wind Music Association) and international music associations.